Novel nucleotide triphosphates as potent P2Y2 agonists

Daniel Brookings; Richard J Davenport; Jeremy Davis; Frances C A Galvin; Steve Lloyd; Stephen R Mack; Ray Owens; Verity Sabin; Joanne Wynn

doi:10.1016/j.bmcl.2006.09.017

Novel nucleotide triphosphates as potent P2Y2 agonists

Bioorg Med Chem Lett. 2007 Jan 15;17(2):562-5. doi: 10.1016/j.bmcl.2006.09.017. Epub 2006 Sep 29.

Authors

Daniel Brookings¹, Richard J Davenport, Jeremy Davis, Frances C A Galvin, Steve Lloyd, Stephen R Mack, Ray Owens, Verity Sabin, Joanne Wynn

Affiliation

¹ UCB-Group, Granta Park, Abington, Cambridge CB1 6GS, UK.

PMID: 17011188
DOI: 10.1016/j.bmcl.2006.09.017

Abstract

The synthesis and P2Y2 activities of a novel series of nucleoside triphosphates are described. Many of these compounds were potent agonists of the P2Y2 receptor.

Publication types

Comparative Study

MeSH terms

Cell Line, Tumor
DNA, Complementary / biosynthesis
DNA, Complementary / genetics
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Nucleotides / chemical synthesis*
Nucleotides / pharmacology*
Purinergic P2 Receptor Agonists*
Receptors, Purinergic P2Y2
Reverse Transcriptase Polymerase Chain Reaction
Structure-Activity Relationship
Uridine Triphosphate / pharmacology

Substances

DNA, Complementary
Indicators and Reagents
Nucleotides
P2RY2 protein, human
Purinergic P2 Receptor Agonists
Receptors, Purinergic P2Y2
Uridine Triphosphate